Selective Androgen Receptor Modulators (SARMs)

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  • Cardarine (GW501516, GW516)
    Cardarine (GW501516, GW516) This drug was first brought to my attention when I saw that many personal trainers were giving it to clients to promote fat loss. I was surprised at the popularity and wanted to delve deep into the research. First described in 1992, Cardarine is a Peroxisome Proliferator-Activated Receptor Delta (PPARD) receptor agonist … Continue reading Cardarine (GW501516, GW516)
  • Are SARMs Safe?
    Are SARMs Safe? The issue is that individuals have different definitions of what ‘Safe’ might mean. Just because something is legal or available Over the counter (OTC) does not make it safe. There is a lot of decision making that goes into the process of scheduling drugs and it would take multiple pages to cover. … Continue reading Are SARMs Safe?
  • S-23
    S-23 This drug was initially developed as a male contraceptive. It is a potent Androgen Receptor agonist (helps activates the receptor) and very selective meaning it binds to bone and muscle, and no other unwanted tissues. Studies of S-23 in humans are lacking however there are in vitro (‘Test Tube’) and in vivo (animal studies) … Continue reading S-23
  • YK-11
    YK-11 First described in 2011. This SARM differs from the other SARMs because it uses an anabolic androgenic steroid backbone but is unique in comparison to Anabolic steroids. Other SARMs are non-steroidal in nature. It only partially activates Androgen Receptors (ARs). Even classification as a SARM is contended by many because of the fact that … Continue reading YK-11
  • RAD 140
    RAD 140 First described in 2010. In vitro studies (‘Test Tube Experiments’) have shown that it has a much higher binding affinity to Androgen Receptors (ARs) than testosterone and dihydrotestosterone (DHT). It strongly binds to bone and muscle ARs. It has also been shown to be highly selective and in fact antagonises (opposes) ARs in … Continue reading RAD 140
  • Andarine (S4)
    Andarine (S4) This is a second generation SARM. There is no conversion to oestrogen. Andarine when compared to testosterone is as anabolic on muscle tissue however has 30-40% fewer androgenicity (Discussed Above). In animal studies it significantly decreased total fat mass. It is more potent at preventing bone loss than DHT. Andarine minimally stimulates the … Continue reading Andarine (S4)
  • Ostarine (MK-2866)
    Ostarine (MK-2866) A second generation SARM. Works strongly at ARs (Androgen Receptors) in the bone, connective tissue and muscle. Weakly binds to ARs in the prostate. This SARM has the most research. It has undergone phase 3 trials. In studies using a dose of only 3mg a day it was shown to increase lean body … Continue reading Ostarine (MK-2866)
  • Ligandrol (LGD-4033)
    Ligandrol (LGD-4033) First described in 2007, it is a a second generation SARM. It has been subject to Phase I clinical trials on humans. In the most referenced study Ligandrol (LGD) was studied in various doses ranging from nothing (the placebo) to 1 mg daily. The studied showed that 1lb of muscle was gained a … Continue reading Ligandrol (LGD-4033)
  • The Basics to Selective Androgen Receptor Modulators (SARMs)
    Foreword The purpose of this blog is not to promote the use of SARMs, rather it is to mitigate the health effects and educate those who decide to utilise SARMs. Medical jargon will be used minimally to reach a broader audience and to decrease misunderstanding. Introduction Selective Androgen Receptor Modulators (SARMs), as stated in the … Continue reading The Basics to Selective Androgen Receptor Modulators (SARMs)
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