The Strongest Steroid: Trenbolone


The Strongest Steroid: Trenbolone

This drug has gained popularity in the fitness industry lately. This is mainly attributed to the memes surrounding this drug. The memes usually mention the fact that Trenbolone (Tren) is a very potent anabolic steroid. Does the science support this notion?

First studied in 1967, Tren was being sold as a veterinary medicine (also briefly sold for human consumption surprisingly). Tren was popular amongst cattle farmers because it increased the rate of weight gain and improved feed efficiency. It was on in the 1980s that this drug gained popularity amongst bodybuilders. It was smuggled at high rates across borders and was used by almost all top tier bodybuilders because it was a powerful anabolic. After 7 years, pharmaceutical companies decided to stop producing the injectable Tren. Pellets were created instead, which could only be used in cattle.

As mentioned above, Tren is an injectable anabolic steroid derived from Nandrolone (“Deca”). Tren is non-oestrogenic (meaning it does not convert to oestrogen) and it is far more potent than Nandrolone. It is like by bodybuilders because it increases muscle hardness, definition, and strength, without water retention or fat gain.

What are the side effects?

Oestrogenic side effects are not typically experienced since this drug does not aromatize to oestrogen. However, Tren is unique in that it binds to progesterone receptors more strongly than progesterone itself. Side effects of this are similar to oestrogenic side effects. Furthermore, progestins aid in oestrogen’s binding to breast tissue, which results in gynecomastia even in the absence of high oestrogen levels. This side effect is more common when an oestrogenic agent is paired with Tren. Anti-oestrogens might aid slightly in reducing this side effect. However, the best treatment is full cessation of Tren.


Trenbolone is sufficiently androgenic and thus typical androgenic side effects should be expected (such as body hair growth, hair loss, acne etc.). Tren is not metabolised by 5 alpha reductase and thus Finasteride does not help in reducing hair loss.

Although Tren is not C-17 alkylated, there are reports of it being resistant to liver breakdown and thus liver toxicity in those abusing it.

Tren does suppress natural testosterone production and therefore a PCT is required for re-establishment of natural testosterone production.

Tren does have a strong negative effect on the Cardiovascular system (the heart), this is attributable to it not being converted to oestrogen (which is cardioprotective) and having liver toxicity. This results in a decrease in HDL (good cholesterol) and increase in LDL (bad cholesterol). Aerobic exercise and a diet low in saturated fats and processed carbohydrates will help mitigate these effects.

Increase risk of Alzheimer’s disease. Tren has been shown, in mice models, to increase amyloid plaque collection in the brain which increase the risk of Alzheimer’s disease.

Tren has been noted to cause night sweating. Carbohydrate timing (not eating them so close to sleep has mitigated this effect).

Tren is also well known for its harsh mental side effects. The typical “Roid Rage” is very likely to be experienced on this drug.

How is it used?
Tren is an injectable and the half life depends on which ester is used. Trenbolone Enanthate has a half-life of 7 to 8 days (meaning that once a week dosing is sufficient) and Trenbolone Acetate has a half-life of 2 to 3 days (meaning every other day dosing is required). It is typically used for 6 to 12 weeks at a dose of 100mg to 300mg a week.

Tren is extremely versatile. Whilst it is known for its ability to aid in fat loss, which is why it is used for contest prep, it is also a very potent muscle builder. The most effective mass building steroid stack is claimed to consist of Testosterone, Trenbolone and Anadrol. Tren stacks well with other drugs, but the choice of agent to stack with Tren depends on the goal of the individual.

Therefore, Tren does live up to its reputation on social media, making it the most potent steroid.


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