RAD 140

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RAD 140

  • First described in 2010.
  • In vitro studies (‘Test Tube Experiments’) have shown that it has a much higher binding affinity to Androgen Receptors (ARs) than testosterone and dihydrotestosterone (DHT).
  • It strongly binds to bone and muscle ARs.
  • It has also been shown to be highly selective and in fact antagonises (opposes) ARs in androgenic tissues.
  • It does not interact with other hormone receptors.
  • It is still in pre-clinical development therefore human studies are not available.
  • In a study using rats, it had a stronger anabolic effect than Testosterone. 40% more testosterone was needed to replicate the anabolic effect of RAD 140.
  • It has a very mild androgenic effect (Masculinizing).
  • As mentioned, it is very selective and thus barely influenced the prostate.
  • RAD 140 has also been shown to be Neuroprotective – An in vitro and in vivo (in an actual animal) study showed that RAD 140 protected neurons from accumulation of Beta-amyloid (a protein postulated to be linked to Alzheimer’s Disease).
  • Although this drug seems to have some favourable characteristics, remember that safety has not been established in humans – currently no human trials.
  • RAD 140 is on the list of banned substances by WADA.

Side Effects:

  • Due to the lack of studies done in humans, we have to rely upon anecdotal reports from users in bodybuilding forums.
  • There appears to be a low liver toxicity.
  • Like other oral androgens, it does decrease good cholesterol (HDL) which poses a risk of cardiovascular disease.
  • In terms of natural testosterone suppression (more correctly referred to as HPTA suppression), anecdotally this drug is suppressive.

Use:

  • It is taken orally.
  • The half life of this drug has been subject to debate. It was originally thought to be 16 to 20 hours which would mean you would have to take the drug once daily, however, it is now believed to be 60 hours.
  • Common doses are 10 to 20mg for men and 5 to 10mg for women.
  • In studies done on monkeys, 0.1mg/kg seemed to produce the same results as 1mg/kg, the caveat being monkeys did not train and training is an important part to assessing the full capability of PEDs.
  • This drug can be dosed daily or once every two days.
  • Due to the lack of reported liver toxicity, cycles tend to range from 6 weeks to 12 weeks. This is subject to change if more studies are published.
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