Ostarine (MK-2866)

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Ostarine (MK-2866)

  • A second generation SARM.
  • Works strongly at ARs (Androgen Receptors) in the bone, connective tissue and muscle.
  • Weakly binds to ARs in the prostate.
  • This SARM has the most research.
  • It has undergone phase 3 trials.
  • In studies using a dose of only 3mg a day it was shown to increase lean body mass by 3%.
  • Furthermore, it has been shown to decrease fasting blood sugar due to better insulin sensitivity.
  • It has a very low androgenicity (Masculinising effects) at 3mg daily, especially shown in studies involving women.
  • It is banned by WADA.

Side Effects

  • Suppresses good cholesterol (HDL).
  • In studies, nausea, headaches, back pain, fatigue, diarrhoea, sore throat, and pain in the extremities (fingers, toes etc) were reported.
  • Also 20% of patients at a dose of 3mg a day had evidence of liver toxicity.
  • Again, side effects depend on the dose.
  • The drug is mildly suppressive on natural testosterone production. However, this was at a dose of 3mg which is lower than that used for bodybuilding.

Use

  • It is taken orally.
  • It has not been approved for human consumption like most SARMs.
  • For performance enhancement it is generally used at 10 to 30 mg once daily.
  • Like most SARMs, a ‘tapering up’ approach is advised. Start at 10mg for the first week and then taper up 5mg each week until a desired level is reached.
  • Since it is not androgenic at lower doses women can use it and expect minimal virilisation.
  • According to forums, this drug is usually taken when one wants to reduce their body fat percentage whilst maintaining muscle mass.
  • In addition, since it has a high affinity for connective tissue ARs, it appears to assist in injuries.
  • Individuals tend to notice a ‘Feel good’ sensation whilst on this compound. The only other known oral steroid to have this affect is Dianabol (Methandienone).
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