- A second generation SARM.
- Works strongly at ARs (Androgen Receptors) in the bone, connective tissue and muscle.
- Weakly binds to ARs in the prostate.
- This SARM has the most research.
- It has undergone phase 3 trials.
- In studies using a dose of only 3mg a day it was shown to increase lean body mass by 3%.
- Furthermore, it has been shown to decrease fasting blood sugar due to better insulin sensitivity.
- It has a very low androgenicity (Masculinising effects) at 3mg daily, especially shown in studies involving women.
- It is banned by WADA.
- Suppresses good cholesterol (HDL).
- In studies, nausea, headaches, back pain, fatigue, diarrhoea, sore throat, and pain in the extremities (fingers, toes etc) were reported.
- Also 20% of patients at a dose of 3mg a day had evidence of liver toxicity.
- Again, side effects depend on the dose.
- The drug is mildly suppressive on natural testosterone production. However, this was at a dose of 3mg which is lower than that used for bodybuilding.
- It is taken orally.
- It has not been approved for human consumption like most SARMs.
- For performance enhancement it is generally used at 10 to 30 mg once daily.
- Like most SARMs, a ‘tapering up’ approach is advised. Start at 10mg for the first week and then taper up 5mg each week until a desired level is reached.
- Since it is not androgenic at lower doses women can use it and expect minimal virilisation.
- According to forums, this drug is usually taken when one wants to reduce their body fat percentage whilst maintaining muscle mass.
- In addition, since it has a high affinity for connective tissue ARs, it appears to assist in injuries.
- Individuals tend to notice a ‘Feel good’ sensation whilst on this compound. The only other known oral steroid to have this affect is Dianabol (Methandienone).