Ligandrol (LGD-4033)


Ligandrol (LGD-4033)

  • First described in 2007, it is a a second generation SARM.
  • It has been subject to Phase I clinical trials on humans.
  • In the most referenced study Ligandrol (LGD) was studied in various doses ranging from nothing (the placebo) to 1 mg daily. The studied showed that 1lb of muscle was gained a week in the 1mg category. Furthermore, the participants of the study did not exercise. Fat mass was not observed to have changed.
  • It is known in the bodybuilding community to be one of the more efficient SARMs at muscle building and is one of the more selective compounds (Meaning less androgenicity).
  • Ligandrol is on the WADA banned substance list.
  • Muscle gains are often compared to that of oxandrolone (Anavar) or Stanozolol (Winstrol).
  • Ligandrol has be shown to decrease sex hormone binding globulin therefore increase free and active hormones (like testosterone) or whichever other anabolic is being used with it.

Side effects:

  • These are dose dependent.
  • In the study, dry mouth and headache were the most reported side effects.
  • This drug also has a 40% reduction of good cholesterol (HDL) when used at only 1mg a day.
  • It highly suppresses natural testosterone production. A PCT is required.
  • Liver toxicity is low.
  • No serious adverse events were reported in doses up to 22 mg per day.


  • 1mg a day or more in the literature appears to be efficacious.
  • For performance enhancement 2 to 10mg are used a day.
  • Taper up the dosage.
  • Start with 1 to 2mg then increase it by a further 1 or 2 mg a day until you reach your desired dosage.
  • Use for a maximum of 8 weeks.
  • A PCT will be required.

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